Ontology highlight
ABSTRACT:
SUBMITTER: Dango S
PROVIDER: S-EPMC3258846 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Dango Sebastian S Mosammaparast Nima N Sowa Mathew E ME Xiong Li-Jun LJ Wu Feizhen F Park Keyjung K Rubin Mark M Gygi Steve S Harper J Wade JW Shi Yang Y
Molecular cell 20111101 3
Demethylation by the AlkB dioxygenases represents an important mechanism for repair of N-alkylated nucleotides. However, little is known about their functions in mammalian cells. We report the purification of the ALKBH3 complex and demonstrate its association with the activating signal cointegrator complex (ASCC). ALKBH3 is overexpressed in various cancers, and both ALKBH3 and ASCC are important for alkylation damage resistance in these tumor cell lines. ASCC3, the largest subunit of ASCC, encod ...[more]