Ontology highlight
ABSTRACT:
SUBMITTER: Qi R
PROVIDER: S-EPMC8434105 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Qi Rui R Bian Ke K Chen Fangyi F Tang Qi Q Zhou Xianhao X Li Deyu D
Molecules (Basel, Switzerland) 20210831 17
Mutation patterns of DNA adducts, such as mutational spectra and signatures, are useful tools for diagnostic and prognostic purposes. Mutational spectra of carcinogens derive from three sources: adduct formation, replication bypass, and repair. Here, we consider the repair aspect of 1,<i>N</i><sup>6</sup>-ethenoadenine (εA) by the 2-oxoglutarate/Fe(II)-dependent AlkB family enzymes. Specifically, we investigated εA repair across 16 possible sequence contexts (5'/3' flanking base to εA varied as ...[more]