Ontology highlight
ABSTRACT:
SUBMITTER: Thorsell AG
PROVIDER: S-EPMC3258897 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Thorsell Ann-Gerd AG Persson Camilla C Voevodskaya Nina N Busam Robert D RD Hammarström Martin M Gräslund Susanne S Gräslund Astrid A Hallberg B Martin BM
The Journal of biological chemistry 20080324 22
Altered inositol metabolism is implicated in a number of diabetic complications. The first committed step in mammalian inositol catabolism is performed by myo-inositol oxygenase (MIOX), which catalyzes a unique four-electron dioxygen-dependent ring cleavage of myo-inositol to D-glucuronate. Here, we present the crystal structure of human MIOX in complex with myo-inosose-1 bound in a terminal mode to the MIOX diiron cluster site. Furthermore, from biochemical and biophysical results from N-termin ...[more]