Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Alvarez R
PROVIDER: S-EPMC5649556 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
González-Álvarez Rafael R Pérez-Ibave Diana Cristina DC Garza-Rodríguez María Lourdes ML Lugo-Trampe Ángel Á Delgado-Enciso Iván I Tejero-Barrera María Elizabeth ME Martínez-De-Villarreal Laura Elia LE Garza-Guajardo Raquel R Sánchez-Chaparro María Marisela MM Ruiz-Ayma Gabriel G Barboza-Quintana Oralia O Barrera-Saldaña Hugo Alberto HA Rocha-Pizaña María Del Refugio MDR Rocha-Pizaña María Del Refugio MDR Rodríguez-Sánchez Irám Pablo IP
Biomedical reports 20170825 4
The enzyme myo-Inositol oxygenase (MIOX) is also termed ALDRL6. It is a kidney-specific member of the aldo-keto reductase family. MIOX catalyzes the first reaction involved in the myo-inositol metabolism signaling pathway and is fully expressed in mammalian tissues. MIOX catalyzes the oxidative cleavage of myo-Inositol and its epimer, D-chiro-Inositol to D-glucuronate. The dioxygen-dependent cleavage of the C6 and C1 bond in myo-Inositol is achieved by utilizing the Fe<sub>2+</sub>/Fe<sub>3+</su ...[more]