Ontology highlight
ABSTRACT:
SUBMITTER: Kagawa W
PROVIDER: S-EPMC3259773 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20080701 35
Rad52 plays essential roles in homology-dependent double-strand break repair. Various studies have established the functions of Rad52 in Rad51-dependent and Rad51-independent repair processes. However, the precise molecular mechanisms of Rad52 in these processes remain unknown. In the present study we have identified a novel DNA binding site within Rad52 by a structure-based alanine scan mutagenesis. This site is closely aligned with the putative single-stranded DNA binding site determined previ ...[more]