Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC4281715 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Li Zheng Z Lee Ashley S E AS Bracher Susanne S Jung Heinrich H Paz Aviv A Kumar Jay P JP Abramson Jeff J Quick Matthias M Shi Lei L
The Journal of biological chemistry 20141114 1
The structure of the sodium/galactose transporter (vSGLT), a solute-sodium symporter (SSS) from Vibrio parahaemolyticus, shares a common structural fold with LeuT of the neurotransmitter-sodium symporter family. Structural alignments between LeuT and vSGLT reveal that the crystallographically identified galactose-binding site in vSGLT is located in a more extracellular location relative to the central substrate-binding site (S1) in LeuT. Our computational analyses suggest the existence of an add ...[more]