Ontology highlight
ABSTRACT:
SUBMITTER: Notomi S
PROVIDER: S-EPMC3260798 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Notomi Shoji S Hisatomi Toshio T Kanemaru Takaaki T Takeda Atsunobu A Ikeda Yasuhiro Y Enaida Hiroshi H Kroemer Guido G Ishibashi Tatsuro T
The American journal of pathology 20111008 6
Stressed cells release ATP, which participates in neurodegenerative processes through the specific ligation of P2RX7 purinergic receptors. Here, we demonstrate that extracellular ATP and the more specific P2RX7 agonist, 2'- and 3'-O-(4-benzoylbenzoyl)-ATP, both induce photoreceptor cell death when added to primary retinal cell cultures or when injected into the eyes from wild-type mice, but not into the eyes from P2RX7(-/-) mice. Photoreceptor cell death was accompanied by the activation of casp ...[more]