Ontology highlight
ABSTRACT:
SUBMITTER: Duan J
PROVIDER: S-EPMC3261567 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Duan Jinzhu J Gherghe Costin C Liu Dianxin D Hamlett Eric E Srikantha Luxman L Rodgers Laurel L Regan Jenna N JN Rojas Mauricio M Willis Monte M Leask Andrew A Majesky Mark M Deb Arjun A
The EMBO journal 20111115 2
Wnts are required for cardiogenesis but the role of specific Wnts in cardiac repair remains unknown. In this report, we show that a dynamic Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. Acute ischaemic cardiac injury upregulates Wnt1 that is initially expressed in the epicardium and subsequently by cardiac fibroblasts in the region of injury. Following cardiac injury, the epicardium is activated organ-wide in a Wnt-dependent manner, exp ...[more]