Ontology highlight
ABSTRACT:
SUBMITTER: Han DY
PROVIDER: S-EPMC3262684 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Han Dong-Yun DY Nie Hong-Guang HG Su Xue-Feng XF Shi Xue-Mei XM Bhattarai Deepa D Zhao Meimi M Zhao Run-Zhen RZ Landers Katlin K Tang Hua H Zhang Lin L Ji Hong-Long HL
American journal of respiratory cell and molecular biology 20110511 5
Salt absorption via alveolar epithelial Na(+) channels (ENaC) is a critical step for maintaining an airspace free of flooding. Previously, we found that 8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphate-Na (CPT-cGMP) activated native and heterologous ENaC. To investigate the potential pharmacological relevance, we applied this compound intratracheally to human lungs and found that ex vivo alveolar fluid clearance was increased significantly. Furthermore, this compound eliminated self-i ...[more]