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Complete sequence of broad-host-range plasmid pRIO-5 harboring the extended-spectrum-?-lactamase gene blaBES??.

ABSTRACT: Broad-host-range plasmid pRIO-5, harboring the extended-spectrum ?-lactamase bla(BES-1) gene in Serratia marcescens, was fully sequenced. Analysis of the 12,957-bp sequence of this IncP6-type plasmid revealed that the bla(BES-1) gene was associated with two copies of the insertion sequence IS26. The promoter responsible for the bla(BES-1) expression was hybrid, made of a -35 box located inside the inverted repeat of IS26 and a -10 box inside a remnant of an insertion sequence.

SUBMITTER: Bonnin RA

PROVIDER: S-EPMC3264251 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Complete sequence of broad-host-range plasmid pRIO-5 harboring the extended-spectrum-β-lactamase gene blaBES₋₁.

Bonnin Rémy A RA Poirel Laurent L Sampaio Jorge Luiz Mello JL Nordmann Patrice P

Antimicrobial agents and chemotherapy 20111114 2

Broad-host-range plasmid pRIO-5, harboring the extended-spectrum β-lactamase bla(BES-1) gene in Serratia marcescens, was fully sequenced. Analysis of the 12,957-bp sequence of this IncP6-type plasmid revealed that the bla(BES-1) gene was associated with two copies of the insertion sequence IS26. The promoter responsible for the bla(BES-1) expression was hybrid, made of a -35 box located inside the inverted repeat of IS26 and a -10 box inside a remnant of an insertion sequence. ...[more]

PMID: 22083487

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