Ontology highlight
ABSTRACT:
SUBMITTER: Riccio DA
PROVIDER: S-EPMC3264784 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Riccio Daniel A DA Nutz Steven T ST Schoenfisch Mark H MH
Analytical chemistry 20111227 2
The concentration of S-nitrosothiols (RSNOs), endogenous transporters of the signaling molecule nitric oxide (NO), fluctuate greatly in physiology often as a function of disease state. RSNOs may be measured indirectly by cleaving the S-N bond and monitoring the liberated NO. While ultraviolet photolysis and reductive-based cleavage both decompose RSNOs to NO, poor selectivity and the need for additional reagents preclude their utility clinically. Herein, we report the coupling of visible photoly ...[more]