Unknown

Dataset Information

0

A bioinformatic assay for pluripotency in human cells.

ABSTRACT: Pluripotent stem cells (PSCs) are defined by their potential to generate all cell types of an organism. The standard assay for pluripotency of mouse PSCs is cell transmission through the germline, but for human PSCs researchers depend on indirect methods such as differentiation into teratomas in immunodeficient mice. Here we report PluriTest, a robust open-access bioinformatic assay of pluripotency in human cells based on their gene expression profiles.

SUBMITTER: Muller FJ 

PROVIDER: S-EPMC3265323 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Pluripotent stem cells (PSCs) are defined by their potential to generate all cell types of an organism. The standard assay for pluripotency of mouse PSCs is cell transmission through the germline, but for human PSCs researchers depend on indirect methods such as differentiation into teratomas in immunodeficient mice. Here we report PluriTest, a robust open-access bioinformatic assay of pluripotency in human cells based on their gene expression profiles. ...[more]

Similar Datasets

Unknown Induced pluripotency of human prostatic epithelial cells.
| S-EPMC3661502 | biostudies-literature
Unknown Standardization of the teratoma assay for analysis of pluripotency of human ES cells and biosafety of their differentiated progeny.
| S-EPMC3458078 | biostudies-literature
Unknown Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays.
| S-EPMC5425621 | biostudies-literature
Unknown In vitro culture-induced pluripotency of human spermatogonial stem cells.
| S-EPMC3591227 | biostudies-literature
Unknown Reprogramming human cells to naive pluripotency: how close are we?
| S-EPMC6112416 | biostudies-literature
Unknown Two factor reprogramming of human neural stem cells into pluripotency.
| S-EPMC2739296 | biostudies-literature
Unknown Proteomic and bioinformatic profile of primary human oral epithelial cells.
| S-EPMC3508721 | biostudies-literature
Unknown Comparative computational analysis of pluripotency in human and mouse stem cells.
| S-EPMC4300513 | biostudies-literature
Unknown Stirred suspension bioreactors maintain naive pluripotency of human pluripotent stem cells.
| S-EPMC7476926 | biostudies-literature
Unknown Reprogramming of human cells to pluripotency induces CENP-A chromatin depletion.
| S-EPMC7653353 | biostudies-literature