Ontology highlight
ABSTRACT:
SUBMITTER: de Rivero Vaccari JP
PROVIDER: S-EPMC3265608 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
de Rivero Vaccari Juan Pablo JP Minkiewicz Julia J Wang Xiaoliang X De Rivero Vaccari Juan Carlos JC German Ramon R Marcillo Alex E AE Dietrich W Dalton WD Keane Robert W RW
Glia 20111207 3
Spinal cord injury (SCI) induces a glial response in which astrocytes become activated and produce inflammatory mediators. The molecular basis for regulation of glial-innate immune responses remains poorly understood. Here, we examined the activation of retinoic acid-inducible gene (RIG)-like receptors (RLRs) and their involvement in regulating inflammation after SCI. We show that astrocytes express two intracellular RLRs: RIG-I and melanoma differentiation-associated gene 5. SCI and stretch inj ...[more]