Ontology highlight
ABSTRACT:
SUBMITTER: Zhao JC
PROVIDER: S-EPMC3266039 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Zhao Jonathan C JC Yu Jianjun J Runkle Christine C Wu Longtao L Hu Ming M Wu Dayong D Liu Jun S JS Wang Qianben Q Qin Zhaohui S ZS Yu Jindan J
Genome research 20111216 2
Androgen receptor (AR) is a hormone-activated transcription factor that plays important roles in prostate development and function, as well as malignant transformation. The downstream pathways of AR, however, are incompletely understood. AR has been primarily known as a transcriptional activator inducing prostate-specific gene expression. Through integrative analysis of genome-wide AR occupancy and androgen-regulated gene expression, here we report AR as a globally acting transcriptional repress ...[more]