Ontology highlight
ABSTRACT:
SUBMITTER: Benlimame N
PROVIDER: S-EPMC2171271 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Benlimame Naciba N He Qiang Q Jie Su S Xiao Dingzhang D Xu Ying Jie YJ Loignon Martin M Schlaepfer David D DD Alaoui-Jamali Moulay A MA
The Journal of cell biology 20051101 3
The overexpression of members of the ErbB tyrosine kinase receptor family has been associated with cancer progression. We demonstrate that focal adhesion kinase (FAK) is essential for oncogenic transformation and cell invasion that is induced by ErbB-2 and -3 receptor signaling. ErbB-2/3 overexpression in FAK-deficient cells fails to promote cell transformation and rescue chemotaxis deficiency. Restoration of FAK rescues both oncogenic transformation and invasion that is induced by ErbB-2/3 in v ...[more]