Ontology highlight
ABSTRACT:
SUBMITTER: van den Akker J
PROVIDER: S-EPMC3266506 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
van den Akker Jeroen J van Weert Angela A Afink Gijs G Bakker Erik N T P EN van der Pol Edwin E Böing Anita N AN Nieuwland Rienk R VanBavel Ed E
Amino acids 20110810 2-3
Transglutaminase 2 (TG2) is a pleiotropic enzyme involved in both intra- and extracellular processes. In the extracellular matrix, TG2 stabilizes the matrix by both covalent cross-linking and disulfide isomerase activity. These functions become especially apparent during matrix remodeling as seen in wound healing, tumor development and vascular remodeling. However, TG2 lacks the signal sequence for a classical secretory mechanism, and the cellular mechanism of TG2 secretion is currently unknown. ...[more]