Ontology highlight
ABSTRACT:
SUBMITTER: Nobile CJ
PROVIDER: S-EPMC3266547 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Nobile Clarissa J CJ Fox Emily P EP Nett Jeniel E JE Sorrells Trevor R TR Mitrovich Quinn M QM Hernday Aaron D AD Tuch Brian B BB Andes David R DR Johnson Alexander D AD
Cell 20120101 1-2
A biofilm is an organized, resilient group of microbes in which individual cells acquire properties, such as drug resistance, that are distinct from those observed in suspension cultures. Here, we describe and analyze the transcriptional network controlling biofilm formation in the pathogenic yeast Candida albicans, whose biofilms are a major source of medical device-associated infections. We have combined genetic screens, genome-wide approaches, and two in vivo animal models to describe a maste ...[more]