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Genetic control of Candida albicans biofilm development.


ABSTRACT: Candida species cause frequent infections owing to their ability to form biofilms - surface-associated microbial communities - primarily on implanted medical devices. Increasingly, mechanistic studies have identified the gene products that participate directly in the development of Candida albicans biofilms, as well as the regulatory circuitry and networks that control their expression and activity. These studies have uncovered new mechanisms and signals that govern C. albicans biofilm development and associated drug resistance, thus providing biological insight and therapeutic foresight.

SUBMITTER: Finkel JS 

PROVIDER: S-EPMC3891587 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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Genetic control of Candida albicans biofilm development.

Finkel Jonathan S JS   Mitchell Aaron P AP  

Nature reviews. Microbiology 20101229 2


Candida species cause frequent infections owing to their ability to form biofilms - surface-associated microbial communities - primarily on implanted medical devices. Increasingly, mechanistic studies have identified the gene products that participate directly in the development of Candida albicans biofilms, as well as the regulatory circuitry and networks that control their expression and activity. These studies have uncovered new mechanisms and signals that govern C. albicans biofilm developme  ...[more]

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