Ontology highlight
ABSTRACT:
SUBMITTER: Cellitti SE
PROVIDER: S-EPMC3267046 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Cellitti Susan E SE Shaffer Jennifer J Jones David H DH Mukherjee Tathagata T Gurumurthy Meera M Bursulaya Badry B Boshoff Helena I HI Choi Inhee I Nayyar Amit A Lee Yong Sok YS Cherian Joseph J Niyomrattanakit Pornwaratt P Dick Thomas T Manjunatha Ujjini H UH Barry Clifton E CE Spraggon Glen G Geierstanger Bernhard H BH
Structure (London, England : 1993) 20120101 1
Tuberculosis continues to be a global health threat, making bicyclic nitroimidazoles an important new class of therapeutics. A deazaflavin-dependent nitroreductase (Ddn) from Mycobacterium tuberculosis catalyzes the reduction of nitroimidazoles such as PA-824, resulting in intracellular release of lethal reactive nitrogen species. The N-terminal 30 residues of Ddn are functionally important but are flexible or access multiple conformations, preventing structural characterization of the full-leng ...[more]