Ontology highlight
ABSTRACT:
SUBMITTER: Haver HL
PROVIDER: S-EPMC4538556 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Haver Hana L HL Chua Adeline A Ghode Pramila P Lakshminarayana Suresh B SB Singhal Amit A Mathema Barun B Wintjens René R Bifani Pablo P
Antimicrobial agents and chemotherapy 20150622 9
Alleviating the burden of tuberculosis (TB) requires an understanding of the genetic basis that determines the emergence of drug-resistant mutants. PA-824 (pretomanid) is a bicyclic nitroimidazole class compound presently undergoing the phase III STAND clinical trial, despite lacking identifiable genetic markers for drug-specific resistant Mycobacterium tuberculosis. In the present study, we aimed to characterize the genetic polymorphisms of spontaneously generated PA-824-resistant mutant strain ...[more]