Ontology highlight
ABSTRACT:
SUBMITTER: Stark MS
PROVIDER: S-EPMC3267896 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Nature genetics 20111225 2
We sequenced eight melanoma exomes to identify new somatic mutations in metastatic melanoma. Focusing on the mitogen-activated protein (MAP) kinase kinase kinase (MAP3K) family, we found that 24% of melanoma cell lines have mutations in the protein-coding regions of either MAP3K5 or MAP3K9. Structural modeling predicted that mutations in the kinase domain may affect the activity and regulation of these protein kinases. The position of the mutations and the loss of heterozygosity of MAP3K5 and MA ...[more]