Ontology highlight
ABSTRACT:
SUBMITTER: Prickett TD
PROVIDER: S-EPMC3947167 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
The Journal of investigative dermatology 20130905 2
Patients with advanced metastatic melanoma have poor prognosis and the genetics underlying its pathogenesis are poorly understood. High-throughput sequencing has allowed comprehensive discovery of somatic mutations in cancer samples. Here, on analysis of our whole-genome and whole-exome sequencing data of 29 melanoma samples, we identified several genes that harbor recurrent nonsynonymous mutations. These included MAP3K5 (mitogen-activated protein kinase kinase kinase-5), which in a prevalence s ...[more]