Ontology highlight
ABSTRACT:
SUBMITTER: Weiss N
PROVIDER: S-EPMC3268438 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Weiss Norbert N Hameed Shahid S Fernández-Fernández José M JM Fablet Katell K Karmazinova Maria M Poillot Cathy C Proft Juliane J Chen Lina L Bidaud Isabelle I Monteil Arnaud A Huc-Brandt Sylvaine S Lacinova Lubica L Lory Philippe P Zamponi Gerald W GW De Waard Michel M
The Journal of biological chemistry 20111130 4
T-type calcium channels represent a key pathway for Ca(2+) entry near the resting membrane potential. Increasing evidence supports a unique role of these channels in fast and low-threshold exocytosis in an action potential-independent manner, but the underlying molecular mechanisms have remained unknown. Here, we report the existence of a syntaxin-1A/Ca(v)3.2 T-type calcium channel signaling complex that relies on molecular determinants that are distinct from the synaptic protein interaction sit ...[more]