Ontology highlight
ABSTRACT:
SUBMITTER: Nicolas CS
PROVIDER: S-EPMC3268861 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Neuron 20120101 2
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). H ...[more]