Ontology highlight
ABSTRACT:
SUBMITTER: Gu W
PROVIDER: S-EPMC3269024 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Gu Wei W Katz Zachary Z Wu Bin B Park Hye Yoon HY Li Deling D Lin Stanley S Wells Amber L AL Singer Robert H RH
Journal of cell science 20120120 Pt 1
Metastasis involves tumor cell detachment from the primary tumor, and acquisition of migratory and invasive capabilities. These capabilities are mediated by multiple events, including loss of cell-cell contact, an increase in focal adhesion turnover and failure to maintain a normal cell polarity. We have previously reported that silencing of the expression of the zipcode-binding protein IMP1/ZBP1 in breast tumor patients is associated with metastasis. IMP1/ZBP1 selectively binds to a group of mR ...[more]