Ontology highlight
ABSTRACT:
SUBMITTER: Beste MT
PROVIDER: S-EPMC3269544 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Beste Michael T MT Lee Dooyoung D King Michael R MR Koretzky Gary A GA Hammer Daniel A DA
Langmuir : the ACS journal of surfaces and colloids 20120104 4
The pattern of T-lymphocyte homing is hypothesized to be controlled by combinations of chemokine receptors and complementary chemokines. Here, we use numerical simulation to explore the relationship among chemokine potency and concentration, signal transduction, and adhesion. We have developed a form of adhesive dynamics-a mechanically accurate stochastic simulation of adhesion-that incorporates stochastic signal transduction using the next subvolume method. We show that using measurable paramet ...[more]