The membrane-distal regions of integrin α cytoplasmic domains contribute differently to integrin inside-out activation.

ABSTRACT: Functioning as signal receivers and transmitters, the integrin α/β cytoplasmic tails (CT) are pivotal in integrin activation and signaling. 18 α integrin subunits share a conserved membrane-proximal region but have a highly diverse membrane-distal (MD) region at their CTs. Recent studies demonstrated that the presence of α CTMD region is essential for talin-induced integrin inside-out activation. However, it remains unknown whether the non-conserved α CTMD regions differently regulate the inside-out activation of integrin. Using α_IIbβ₃, α_Lβ₂, and α₅β₁ as model integrins and by replacing their α CTMD regions with those of α subunits that pair with β₃, β₂, and β₁ subunits, we analyzed the funct

SUBMITTER: Thinn AMM 

PROVIDER: S-EPMC5864728 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature