The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use.
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ABSTRACT:
SUBMITTER: Perera PY
PROVIDER: S-EPMC3270128 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
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The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use.
Perera Pin-Yu PY Lichy Jack H JH Waldmann Thomas A TA Perera Liyanage P LP
Microbes and infection 20111025 3
Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in many diverse cell types. It plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. This review provides an overview of the mechanisms by which IL-15 modulates the host response to infectious agents and its utility as a cytokine adjuvant in vaccines against infect ...[more]
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