Ontology highlight
ABSTRACT:
SUBMITTER: Golomb L
PROVIDER: S-EPMC3270374 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Golomb Lior L Bublik Debora Rosa DR Wilder Sylvia S Nevo Reinat R Kiss Vladimir V Grabusic Kristina K Volarevic Sinisa S Oren Moshe M
Molecular cell 20120101 2
Members of the β-karyopherin family mediate nuclear import of ribosomal proteins and export of ribosomal subunits, both required for ribosome biogenesis. We report that transcription of the β-karyopherin genes importin 7 (IPO7) and exportin 1 (XPO1), and several additional nuclear import receptors, is regulated positively by c-Myc and negatively by p53. Partial IPO7 depletion triggers p53 activation and p53-dependent growth arrest. Activation of p53 by IPO7 knockdown has distinct features of rib ...[more]