Ontology highlight
ABSTRACT:
SUBMITTER: Nadtochiy SM
PROVIDER: S-EPMC3271010 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Nadtochiy Sergiy M SM Zhu Qiuyu Martin QM Urciuoli William W Rafikov Ruslan R Black Stephen M SM Brookes Paul S PS
The Journal of biological chemistry 20111209 5
Electrophilic nitrated lipids (nitroalkenes) are emerging as an important class of protective cardiovascular signaling molecules. Although species such as nitro-linoleate (LNO(2)) and nitro-oleate can confer acute protection against cardiac ischemic injury, their mechanism of action is unclear. Mild uncoupling of mitochondria is known to be cardioprotective, and adenine nucleotide translocase 1 (ANT1) is a key mediator of mitochondrial uncoupling. ANT1 also contains redox-sensitive cysteines tha ...[more]