Ontology highlight
ABSTRACT:
SUBMITTER: Kliment CR
PROVIDER: S-EPMC7929926 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Kliment Corrine R CR Nguyen Jennifer M K JMK Kaltreider Mary Jane MJ Lu YaWen Y Claypool Steven M SM Radder Josiah E JE Sciurba Frank C FC Zhang Yingze Y Gregory Alyssa D AD Iglesias Pablo A PA Sidhaye Venkataramana K VK Robinson Douglas N DN
Journal of cell science 20210225 4
Airway hydration and ciliary function are critical to airway homeostasis and dysregulated in chronic obstructive pulmonary disease (COPD), which is impacted by cigarette smoking and has no therapeutic options. We utilized a high-copy cDNA library genetic selection approach in the amoeba <i>Dictyostelium discoideum</i> to identify genetic protectors to cigarette smoke. Members of the mitochondrial ADP/ATP transporter family adenine nucleotide translocase (ANT) are protective against cigarette smo ...[more]