Ontology highlight
ABSTRACT:
SUBMITTER: Walther K
PROVIDER: S-EPMC327125 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
Walther Kristin K Diril M Kasim MK Jung Nadja N Haucke Volker V
Proceedings of the National Academy of Sciences of the United States of America 20040115 4
Synaptic vesicle recycling is in part mediated by clathrin-mediated endocytosis. This process involves the coordinated assembly of clathrin and adaptor proteins and the concomitant selection of cargo proteins. Here, we demonstrate that the endocytotic protein stonin 2 localizes to axonal vesicle clusters through its micro-homology domain. Interaction of this domain with synaptotagmin I is sufficient to recruit stonin 2 to the plasmalemma. The N-terminal domain of stonin 2 harbors multiple AP-2-i ...[more]