Ontology highlight
ABSTRACT:
SUBMITTER: Kyung JW
PROVIDER: S-EPMC5282494 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Kyung Jae Won JW Cho In Ha IH Lee Sukmook S Song Woo Keun WK Ryan Timothy A TA Hoppa Michael B MB Kim Sung Hyun SH
Scientific reports 20170131
The complexity and diversity of a neural network requires regulated elongation and branching of axons, as well as the formation of synapses between neurons. In the present study we explore the role of AP-2, a key endocytic adaptor protein complex, in the development of rat hippocampal neurons. We found that the loss of AP-2 during the early stage of development resulted in impaired axon extension and failed maturation of the axon initial segment (AIS). Normally the AIS performs two tasks in conc ...[more]