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Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol.

ABSTRACT: An atom-economical purification protocol, using solution phase processing via ring-opening metathesis polymerization (ROMP) has been developed for the synthesis of tricyclic sultams. This chromatography-free method allows for convenient isolation of reductive-Heck products and reclamation of excess starting material via sequestration involving metathesis catalysts and a catalyst-armed Si-surface.

SUBMITTER: Asad N

PROVIDER: S-EPMC3271945 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol.

Asad Naeem N Hanson Paul R PR Long Toby R TR Rayabarapu Dinesh K DK Rolfe Alan A

Chemical communications (Cambridge, England) 20110705 33

An atom-economical purification protocol, using solution phase processing via ring-opening metathesis polymerization (ROMP) has been developed for the synthesis of tricyclic sultams. This chromatography-free method allows for convenient isolation of reductive-Heck products and reclamation of excess starting material via sequestration involving metathesis catalysts and a catalyst-armed Si-surface. ...[more]

PMID: 21727956

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