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Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy.

ABSTRACT: The construction of a 96-member library of triazolated 1,2,5-thiadiazepane 1,1-dioxides was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 94 out of 96 possible products. The key step, a one-pot, sequential elimination, double-aza-Michael reaction, and [3 + 2] Huisgen cycloaddition pathway has been automated and utilized in the production of two sets of triazolated sultam products.

SUBMITTER: Zang Q 

PROVIDER: S-EPMC3656823 | biostudies-other | 2012 Aug

REPOSITORIES: biostudies-other

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Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy.

Zang Qin Q   Javed Salim S   Hill David D   Ullah Farman F   Bi Danse D   Porubsky Patrick P   Neuenswander Benjamin B   Lushington Gerald H GH   Santini Conrad C   Organ Michael G MG   Hanson Paul R PR  

ACS combinatorial science 20120801 8

The construction of a 96-member library of triazolated 1,2,5-thiadiazepane 1,1-dioxides was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 94 out of 96 possible products. The key step, a one-pot, sequential elimination, double-aza-Michael reaction, and [3 + 2] Huisgen cycloaddition pathway has been automated and utilized in the production of two sets of triazolated sultam products. ...[more]

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