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Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy.

ABSTRACT: The construction of a 96-member library of triazolated 1,2,5-thiadiazepane 1,1-dioxides was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 94 out of 96 possible products. The key step, a one-pot, sequential elimination, double-aza-Michael reaction, and [3 + 2] Huisgen cycloaddition pathway has been automated and utilized in the production of two sets of triazolated sultam products.

SUBMITTER: Zang Q

PROVIDER: S-EPMC3656823 | biostudies-other | 2012 Aug

REPOSITORIES: biostudies-other

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Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy.

Zang Qin Q Javed Salim S Hill David D Ullah Farman F Bi Danse D Porubsky Patrick P Neuenswander Benjamin B Lushington Gerald H GH Santini Conrad C Organ Michael G MG Hanson Paul R PR

ACS combinatorial science 20120801 8

The construction of a 96-member library of triazolated 1,2,5-thiadiazepane 1,1-dioxides was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 94 out of 96 possible products. The key step, a one-pot, sequential elimination, double-aza-Michael reaction, and [3 + 2] Huisgen cycloaddition pathway has been automated and utilized in the production of two sets of triazolated sultam products. ...[more]

PMID: 22853708

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