Ontology highlight
ABSTRACT:
SUBMITTER: Dang Q
PROVIDER: S-EPMC327199 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
Dang Que Q Chen Jianbo J Unutmaz Derya D Coffin John M JM Pathak Vinay K VK Powell Douglas D KewalRamani Vineet N VN Maldarelli Frank F Hu Wei-Shau WS
Proceedings of the National Academy of Sciences of the United States of America 20040105 2
Cells infected with two related retroviruses can generate heterozygous virions, which are the precursors of recombinant proviruses. Although many studies have focused on the frequencies and mechanisms of retroviral recombination, little is known about the dynamics of double infection. To examine this issue, viruses generated from two HIV-1 vectors containing different markers were mixed together, and were used to infect target cells. The numbers of cells expressing none, one, or both markers wer ...[more]