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B cell responses to HIV-1 infection and vaccination: pathways to preventing infection.

ABSTRACT: The B cell arm of the immune response becomes activated soon after HIV-1 transmission, yet the initial antibody response does not control HIV-1 replication, and it takes months for neutralizing antibodies to develop against the autologous virus. Antibodies that can be broadly protective are made only in a minority of subjects and take years to develop--too late to affect the course of disease. New studies of the earliest stages of HIV-1 infection, new techniques to probe the human B cell repertoire, the modest degree of efficacy in a vaccine trial and new studies of human monoclonal antibodies that represent the types of immune responses an HIV-1 vaccine should induce are collectively illuminating paths that a successful HIV-1 vaccine might take.

SUBMITTER: Haynes BF

PROVIDER: S-EPMC3053087 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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B cell responses to HIV-1 infection and vaccination: pathways to preventing infection.

Haynes Barton F BF Moody M Anthony MA Liao Hua-Xin HX Verkoczy Laurent L Tomaras Georgia D GD

Trends in molecular medicine 20101126 2

The B cell arm of the immune response becomes activated soon after HIV-1 transmission, yet the initial antibody response does not control HIV-1 replication, and it takes months for neutralizing antibodies to develop against the autologous virus. Antibodies that can be broadly protective are made only in a minority of subjects and take years to develop--too late to affect the course of disease. New studies of the earliest stages of HIV-1 infection, new techniques to probe the human B cell reperto ...[more]

PMID: 21112250

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