Ontology highlight
ABSTRACT:
SUBMITTER: Kwon H
PROVIDER: S-EPMC3272079 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Kwon Hyokjoon H Thierry-Mieg Danielle D Thierry-Mieg Jean J Kim Hyoung-Pyo HP Oh Jangsuk J Tunyaplin Chainarong C Carotta Sebastian S Donovan Colleen E CE Goldman Matthew L ML Tailor Prafullakumar P Ozato Keiko K Levy David E DE Nutt Stephen L SL Calame Kathryn K Leonard Warren J WJ
Immunity 20091201 6
Interleukin-21 (IL-21) is a pleiotropic cytokine that induces expression of transcription factor BLIMP1 (encoded by Prdm1), which regulates plasma cell differentiation and T cell homeostasis. We identified an IL-21 response element downstream of Prdm1 that binds the transcription factors STAT3 and IRF4, which are required for optimal Prdm1 expression. Genome-wide ChIP-Seq mapping of STAT3- and IRF4-binding sites showed that most regions with IL-21-induced STAT3 binding also bound IRF4 in vivo an ...[more]