Ontology highlight
ABSTRACT:
SUBMITTER: Campos Carrascosa L
PROVIDER: S-EPMC5437292 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Campos Carrascosa Lucia L Klein Matthias M Kitagawa Yohko Y Lückel Christina C Marini Federico F König Anika A Guralnik Anna A Raifer Hartmann H Hagner-Benes Stefanie S Rädler Diana D Böck Andreas A Kang Cholho C Lohoff Michael M Garn Holger H Schaub Bianca B Berberich-Siebelt Friederike F Sakaguchi Shimon S Bopp Tobias T Huber Magdalena M
Nature communications 20170512
The T helper 9 (Th9) cell transcriptional network is formed by an equilibrium of signals induced by cytokines and antigen presentation. Here we show that, within this network, two interferon regulatory factors (IRF), IRF1 and IRF4, display opposing effects on Th9 differentiation. IRF4 dose-dependently promotes, whereas IRF1 inhibits, IL-9 production. Likewise, IRF1 inhibits IL-9 production by human Th9 cells. IRF1 counteracts IRF4-driven Il9 promoter activity, and IRF1 and IRF4 have opposing fun ...[more]