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ABSTRACT: Objective
This was a pilot randomised controlled trial (RCT) to investigate the effect of post-operative face-down positioning on the outcome of macular hole surgery and to inform the design of a larger definitive study.Methods
In all, 30 phakic eyes of 30 subjects with idiopathic full-thickness macular holes underwent vitrectomy with dye-assisted peeling of the ILM and 14% perfluoropropane gas. Subjects were randomly allocated to posture face down for 10 days (posturing group) or to avoid a face-up position only (non-posturing group). The primary outcome was anatomical hole closure.Results
Macular holes closed in 14 of 15 eyes (93.3%; 95% confidence interval (CI) 68-100%) in the posturing group and in 9 of 15 (60%; 95% CI 32-84%) in the non-posturing group. In a subgroup analysis of outcome according to macular hole size, all holes smaller than 400 ?m closed regardless of posturing (100%). In contrast, holes larger than 400 ?m closed in 10 of 11 eyes (91%; 95% CI 58-99%) in the posturing group and in only 4 of 10 eyes (40%; 95% CI 12-74%) in the non-posturing group (Fisher's exact test P=0.02).Conclusion
Post-operative face-down positioning may improve the likelihood of macular hole closure, particularly for holes larger than 400 ?m. These results support the case for a RCT.
SUBMITTER: Lange CA
PROVIDER: S-EPMC3272183 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Lange C A K CA Membrey L L Ahmad N N Wickham L L Maclaren R E RE Solebo L L Xing W W Bunce C C Ezra E E Charteris D D Aylward B B Yorston D D Gregor Z Z Zambarakji H H Bainbridge J W JW
Eye (London, England) 20110923 2
<h4>Objective</h4>This was a pilot randomised controlled trial (RCT) to investigate the effect of post-operative face-down positioning on the outcome of macular hole surgery and to inform the design of a larger definitive study.<h4>Methods</h4>In all, 30 phakic eyes of 30 subjects with idiopathic full-thickness macular holes underwent vitrectomy with dye-assisted peeling of the ILM and 14% perfluoropropane gas. Subjects were randomly allocated to posture face down for 10 days (posturing group) o ...[more]