Ontology highlight
ABSTRACT:
SUBMITTER: Hong SH
PROVIDER: S-EPMC3272573 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Hong Seok Hoon SH Hegde Manjunath M Kim Jeongyun J Wang Xiaoxue X Jayaraman Arul A Wood Thomas K TK
Nature communications 20120103
To utilize biofilms for chemical transformations in biorefineries they need to be controlled and replaced. Previously, we engineered the global regulator Hha and cyclic diguanylate-binding BdcA to create proteins that enable biofilm dispersal. Here we report a biofilm circuit that utilizes these two dispersal proteins along with a population-driven quorum-sensing switch. With this synthetic circuit, in a novel microfluidic device, we form an initial colonizer biofilm, introduce a second cell typ ...[more]