Ontology highlight
ABSTRACT:
SUBMITTER: Lavasani M
PROVIDER: S-EPMC3272577 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Lavasani Mitra M Robinson Andria R AR Lu Aiping A Song Minjung M Feduska Joseph M JM Ahani Bahar B Tilstra Jeremy S JS Feldman Chelsea H CH Robbins Paul D PD Niedernhofer Laura J LJ Huard Johnny J
Nature communications 20120103
With ageing, there is a loss of adult stem cell function. However, there is no direct evidence that this has a causal role in ageing-related decline. We tested this using muscle-derived stem/progenitor cells (MDSPCs) in a murine progeria model. Here we show that MDSPCs from old and progeroid mice are defective in proliferation and multilineage differentiation. Intraperitoneal administration of MDSPCs, isolated from young wild-type mice, to progeroid mice confer significant lifespan and healthspa ...[more]