Ontology highlight
ABSTRACT:
SUBMITTER: Parrinello S
PROVIDER: S-EPMC4940195 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
Parrinello Simona S Samper Enrique E Krtolica Ana A Goldstein Joshua J Melov Simon S Campisi Judith J
Nature cell biology 20030801 8
Most mammalian cells do not divide indefinitely, owing to a process termed replicative senescence. In human cells, replicative senescence is caused by telomere shortening, but murine cells senesce despite having long stable telomeres. Here, we show that the phenotypes of senescent human fibroblasts and mouse embryonic fibroblasts (MEFs) differ under standard culture conditions, which include 20% oxygen. MEFs did not senesce in physiological (3%) oxygen levels, but underwent a spontaneous event t ...[more]