Ontology highlight
ABSTRACT:
SUBMITTER: Sasaki J
PROVIDER: S-EPMC3273392 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Sasaki Jun J Ishikawa Kumiko K Arita Minetaro M Taniguchi Koki K
The EMBO journal 20111129 3
Phosphatidylinositol 4-kinase IIIβ (PI4KB) is a host factor required for genome RNA replication of enteroviruses, small non-enveloped viruses belonging to the family Picornaviridae. Here, we demonstrated that PI4KB is also essential for genome replication of another picornavirus, Aichi virus (AiV), but is recruited to the genome replication sites by a different strategy from that utilized by enteroviruses. AiV non-structural proteins, 2B, 2BC, 2C, 3A, and 3AB, interacted with a Golgi protein, ac ...[more]