Ontology highlight
ABSTRACT:
SUBMITTER: Mills H
PROVIDER: S-EPMC3273394 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Mills Holly H Wragg Rachel R Hapiak Vera V Castelletto Michelle M Zahratka Jeffrey J Harris Gareth G Summers Philip P Korchnak Amanda A Law Wenjing W Bamber Bruce B Komuniecki Richard R
The EMBO journal 20111129 3
Pain modulation is complex, but noradrenergic signalling promotes anti-nociception, with α(2)-adrenergic agonists used clinically. To better understand the noradrenergic/peptidergic modulation of nociception, we examined the octopaminergic inhibition of aversive behaviour initiated by the Caenorhabditis elegans nociceptive ASH sensory neurons. Octopamine (OA), the invertebrate counterpart of norepinephrine, modulates sensory-mediated reversal through three α-adrenergic-like OA receptors. OCTR-1 ...[more]