Ontology highlight
ABSTRACT:
SUBMITTER: Costa A
PROVIDER: S-EPMC3273589 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Costa Alessandro A Gupta Rahul R Signorino Giacomo G Malara Antonio A Cardile Francesco F Biondo Carmelo C Midiri Angelina A Galbo Roberta R Trieu-Cuot Patrick P Papasergi Salvatore S Teti Giuseppe G Henneke Philipp P Mancuso Giuseppe G Golenbock Douglas T DT Beninati Concetta C
Journal of immunology (Baltimore, Md. : 1950) 20120116 4
Group B Streptococcus (GBS) is a frequent agent of life-threatening sepsis and meningitis in neonates and adults with predisposing conditions. We tested the hypothesis that activation of the inflammasome, an inflammatory signaling complex, is involved in host defenses against this pathogen. We show in this study that murine bone marrow-derived conventional dendritic cells responded to GBS by secreting IL-1β and IL-18. IL-1β release required both pro-IL-1β transcription and caspase-1-dependent pr ...[more]