Prostaglandin E2 promotes intestinal tumor growth via DNA methylation.
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ABSTRACT:
SUBMITTER: Xia D
PROVIDER: S-EPMC3274627 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Prostaglandin E2 promotes intestinal tumor growth via DNA methylation.
Xia Dianren D Wang Dingzhi D Kim Sun-Hee SH Katoh Hiroshi H DuBois Raymond N RN
Nature medicine 20120122 2
Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E(2) (PGE(2)) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE(2) in the promotion of tumor prog ...[more]
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