Ontology highlight
ABSTRACT:
SUBMITTER: Crittenden S
PROVIDER: S-EPMC7880593 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Crittenden Siobhan S Goepp Marie M Pollock Jolinda J Robb Calum T CT Smyth Danielle J DJ Zhou You Y Andrews Robert R Tyrrell Victoria V Gkikas Konstantinos K Adima Alexander A O'Connor Richard A RA Davies Luke L Li Xue-Feng XF Yao Hatti X HX Ho Gwo-Tzer GT Zheng Xiaozhong X Mair Amil A Vermeren Sonja S Qian Bin-Zhi BZ Mole Damian J DJ Gerasimidis Konstantinos K Schwarze Jürgen K J JKJ Breyer Richard M RM Arends Mark J MJ O'Donnell Valerie B VB Iredale John P JP Anderton Stephen M SM Narumiya Shuh S Maizels Rick M RM Rossi Adriano G AG Howie Sarah E SE Yao Chengcan C
Science advances 20210212 7
The gut microbiota fundamentally regulates intestinal homeostasis and disease partially through mechanisms that involve modulation of regulatory T cells (T<sub>regs</sub>), yet how the microbiota-T<sub>reg</sub> cross-talk is physiologically controlled is incompletely defined. Here, we report that prostaglandin E<sub>2</sub> (PGE<sub>2</sub>), a well-known mediator of inflammation, inhibits mucosal T<sub>regs</sub> in a manner depending on the gut microbiota. PGE<sub>2</sub> through its receptor ...[more]