Ontology highlight
ABSTRACT:
SUBMITTER: Ntziachristos P
PROVIDER: S-EPMC3274628 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Ntziachristos Panagiotis P Tsirigos Aristotelis A Van Vlierberghe Pieter P Nedjic Jelena J Trimarchi Thomas T Flaherty Maria Sol MS Ferres-Marco Dolors D da Ros Vanina V Tang Zuojian Z Siegle Jasmin J Asp Patrik P Hadler Michael M Rigo Isaura I De Keersmaecker Kim K Patel Jay J Huynh Tien T Utro Filippo F Poglio Sandrine S Samon Jeremy B JB Paietta Elisabeth E Racevskis Janis J Rowe Jacob M JM Rabadan Raul R Levine Ross L RL Brown Stuart S Pflumio Francoise F Dominguez Maria M Ferrando Adolfo A Aifantis Iannis I
Nature medicine 20120206 2
T cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we report the presence of loss-of-function mutations and deletions of the EZH2 and SUZ12 genes, which encode crucial components of the Polycomb repressive complex 2 (PRC2), in 25% of T-ALLs. To further study the role of PRC2 in T-ALL, we used NOTCH1-dependent mouse models of the disease, as well as human T-ALL samples, and combined locus-spe ...[more]