Ontology highlight
ABSTRACT:
SUBMITTER: Siemerink MJ
PROVIDER: S-EPMC3274677 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Siemerink Martin J MJ Klaassen Ingeborg I Vogels Ilse M C IM Griffioen Arjan W AW Van Noorden Cornelis J F CJ Schlingemann Reinier O RO
Angiogenesis 20120117 1
The functional shift of quiescent endothelial cells into tip cells that migrate and stalk cells that proliferate is a key event during sprouting angiogenesis. We previously showed that the sialomucin CD34 is expressed in a small subset of cultured endothelial cells and that these cells extend filopodia: a hallmark of tip cells in vivo. In the present study, we characterized endothelial cells expressing CD34 in endothelial monolayers in vitro. We found that CD34-positive human umbilical vein endo ...[more]